Studies the Stephenson Cardiac Imaging Centre is leading
MAPIT-CRT
A multi-centre randomized controlled trial of MRI-based models to guide optimal lead delivery in CRT. Comprehensive baseline and serial follow-up at 3, 6, and 12 months of patients undergoing CRT. Participants receive a MRI at baseline, an Echocardiogram at baseline, 3 months, and 6 months, a MUGA at baseline and 6 months, as well as a quality of life assessment along with a 6 minute hall walk at baseline, 3 months, and 6 months.
CIROC: The Cardiovascular Imaging Registry of Calgary
A prospective registry designed to link the performance of CMR imaging, catageorized according to Appropriate Use Criteria, to therapeutic decisions and relevant clinical and cost-based outcomes. Patients also have standardized assessments using novel MRI techniques. CIROC is partnered with AHS analytics to collect administrative data related to health care resource consumption and costing, procedural performance and outcomes. A total of 10,000 patients undergoing CMR and 2,500 undergoing echocardiography will be enrolled over the next 5 years. Participants receive annual follow-up for up to 10 years after enrollment.
CanCARD-MR (IMAGE-HF Iia)
A multi-centre registry of patients with ischemic or non-ischemic heart disease accepted for primary prevention ICD implantation. All patients undergo an MRI evaluation to identify the amount and characteristics of scar tissue in the heart. These are being looked at as tools to predict future arrhythmic events.
REFINE ICD – Calgary MRI sub-study
A prospective cohort study of patients receiving ICD following acute myocardial infarction examining the influence of total scar burden on outcomes in ischemic versus non-ischemic cardiomyopathy.
PRE-PROCEDURAL 3D CARDIAC MODELLING to guide Electrophysiologic interventions (Post Doctoral Research)
The creation of a comprehensive architecture for the planning and modeling of electrophysiologic interventions. This incorporates 2D and 3D image segmentation techniques, 4D strain analysis, 3 and 4D modeling and novel image visualization pathways
HCM-FABRY Screening Study
A prospective study examining the role of T1 mapping, 4D Strain analysis and Late Gadolinium Enhancement Imaging in detecting Fabry disease among patients referred for the evalaution of Hypertrophic Cardiomyopathy.
CArdiotoxicity Prevention Research Investigators (CAPRI)
A provincial initiative coordinated by the Stephenson Cardiac Imaging Centre to establish multi-parametric risk prediction models for the development of Cardiotoxicity among patients receiving chemotherapy for Breast Cancer or Lymphoma. This study will evaluate novel MRI, Echocardiographic, Autonomic and Biomarker tests for their capacity to identify those at the earliest stages of heart damage.
HISTOLOGIC VALIDATION OF TISSUE MAPPING in Acute Myocardial Infarction
Using a porcine model of myocardial infarction T1 and T2 mapping techniques are being studied against histologic markers of tissue necrosis, inflammation and fibrosis. This research is partnered with Dr Paul Fedak's research laboratory.
DIALYSIS Cohort Studies
A group of studies evaluating the role of CMR to identify changes in heart tissue thickness, health and mechanical activity during exposure to varying forms of dialysis (renal replacement therapy). This includes collaborations with Centres in Ontario and the UK.
METABOLIC SYNDROME Cohort Study
A prospective cohort study in patients with diabetes, evaluating the capacity of Tissue mapping and strain analysis by MRI to identify patients with early cardiomyopathy.
ADOLESCENT OBESITY Study
A study examining changes in heart function and structure in the young with higher than expected body mass index..
VOLTAGES (Pre-CRT/D) – Voltage gradient to identify scar
A prospective study examining the ability of high resolution ECG to detect regional myocardial scar and lack of biventricular capture among patients referred for CRT. A study partnered with Dr Derek Exner's research lab.
MYOCARDITIS Registry
A prospective multi-centre cohort study evaluating the prognostic utility of CMR measures in patients with acute myocarditis.
SIGNALS (High-resolution Holter)
A study examining the relationship between ECG signals with a high resolution Holter monitor during two rest periods and a 6-minute walk and the size and function of the heart. A study partnered with Dr Derek Exner's research lab.
CHRONIC IRON DEPOSITION PREDICTION OF ARRHYTHMIC EVENTS
A prospective cohort study of patients with prior myocardial infarction to identify chronic iron deposition related to peri-infarction hemorrhage and its prognostic value for future arrhythmic events. This study is partnered with Cedars-Sinae Medical Centre in LA (Dr Rohan Dharmakumar)
3D SPECKLE TRACKING ECHOCARDIOGRAPHY FOR THE EVALUATION OF RIGHT VENTRICULAR DISEASE
A group studies led by Dr Nowell Fine evaluating 3D echocardiography for the detection and quantification of RV dysfunction. This is partnered with Dr Satriano with cross-validation to 4D CMR-based strain analysis.
3T VERSUS 1.5T T1 MAPPING Study
Healthy volunteer study to characterize both SASHA and ShMOLLI based mapping techniques at 1.5 and 3T
4D CT-BASED AORTIC STRAIN ANALYSIS IN PATIENTS WITH AORTIC STENOSIS
A retrospective cohort study evaluating the capacity of 4D strain analysis from cardiac-gated CTA to identify aortopathy (aortic strain) and to evaluate markers of LV decompensation (LV strain)
Studies the Stephenson Cardiac Imaging Centre is participating in
Alberta Heart Study
A prospective multi-centre study to develop the new diagnostic criteria for diastolic heart failure, including imaging, biomarkers, and vascular physiology. The MRI sub-study is a partnered effort between Edmonton (PI: Richard Thompson) and the Stephenson Cardiac Imaging Centre.
IMAGE-HF 1a
A multi-centre randomized controlled trial and registry of patients with ischemic heart failure, randomized to routine care vs advanced imaging (MRI or PET). QA Core lab at Stephenson Cardiac Imaging Centre.
IMAGE-HF 1b
A multi-centre randomized controlled trial and registry of patients with non-ischemic heart failure, randomized to an echocardiogram only versus echocardiogram along with MRI.
ISCHEMIA Trial
A multi-centre, multi-national study evaluating the diagnostic accuracy and prognostic utility of stress perfusion MRI.
HCM Registry (Novel Predictors of Outcome in Hypertrophic Cardiomyopathy)
The aim of this study is to develop a predictive model of cardiovascular outcomes in hypertrophic cardiomyopathy (HCM) by: 1) using exploratory data mining methods to identify demographic, clinical, and novel cardiac magnetic resonance imaging, genetic and biomarker variables associated with the outcomes and 2) develop a score from the predictive model that can be used to assess risk given a patient’s combination of risk factors, thus establishing the evidence base to enable clinical trial design to reduce morbidity and mortality in HCM in a cost- effective manner.
MITNEC B5: Stress Perfusion Imaging Using CMR
A prospective multi-centre cohort study comparing diagnostic accuracy of SPECT MPI versus CMR perfusion for detection of obstructive CAD.
CAIN – CTA Substudy
A prospective study evaluating the ability of a Computed Tomographic Angiogram to predict the risk of a heart attack compared to an intracoronary angiogram and an intravascular ultrasound.
